Adam P. Rosebrock, Ph.D.

Stony Brook School of Medicine

Advancing Metabolomics: Small Molecule Mass Spectrometry Reveals New Biochemical Pathways

Adam P. Rosebrock, Ph.D., Assistant Professor of Pathology and Member, Cancer Center, Stony Brook School of Medicine describes how the latest mass spectrometry technologies are advancing the field of small molecule metabolomics. Hear how the Rosebrock lab is working to develop new mass spectrometry assays to measure the biochemical contents of cells to identify new metabolites and biochemical pathways.

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Adam P. Rosebrock, Ph.D.
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Adam P. Rosebrock, Ph.D.

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Adam P. Rosebrock, Ph.D., is... More

Adam P. Rosebrock, Ph.D.

Stony Brook School of Medicine

Adam P. Rosebrock, Ph.D., is Assistant Professor of Pathology and Member of the Cancer Center at Stony Brook School of Medicine. Dr. Rosebrock’s research is focused on understanding the regulation of central carbon metabolism underlying cell growth and division. The Rosebrock lab is interested in identifying biochemical pathways that respond to changes to internal and external cell state, and to understanding how these responses are enacted – whether through transcriptional regulation, posttranslational modification, or direct regulation of enzymatic activity. The lab uses a combination of genetics, direct biochemical measurement, and extensive computational analysis to understand cellular biochemical state. Genetic tools are used to build model systems with altered pathways and enzyme function, and the group develops and uses a range of mass spectrometry assays to measure biochemical contents and reaction rates of the cell. The Rosebrock lab builds new algorithms to deal with the large amounts of data generated; the group is particularly interested in using “big data” approaches to uncover how distinct biochemical pathways are co-regulated, and to place newly discovered metabolites within greater biological context.