Dr. Naomi Habib,

Hebrew University of Jerusalem

Profiling Alzheimer's disease pathology using single-nucleus RNA sequencing

Watch this video to learn about the novel way in which Dr. Naomi Habib, Associate Professor in brain sciences at the Hebrew University of Jerusalem, is profiling aging-related pathology in the brain to gain a better understanding of disease progression and insight for novel therapeutic development.

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Dr. Naomi Habib,
Neurobiology

Dr. Naomi Habib,

Biography

Associate Professor in brain sciences More
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Dr. Naomi Habib,

Hebrew University of Jerusalem

We are interested in solving the secret of cognitive resilience. The cellular microenvironment in the brain is composed of multiple cell types, including neurons, astrocytes, microglia, vascular and other cells, and we are studying how interactions between different cell types in the brain are contributing to cognitive decline and to cognitive resilience, in particular in the context of aging-related pathologies. We also study how interactions between the brain and other systems in the aging body, such as immune and metabolic signaling, are mediating aging-related pathologies. The work is done using human brain tissue, animal models and cell cultures, combining cutting-edge technologies in the fields of genomics, imaging, molecular biology, and genome engineering, with advanced computational analysis and modeling. Specifically, we are pioneering the development and application of single nucleus RNA-sequencing technologies.