Gene editing technologies have shown incredible promise in health and disease research, particularly for identifying and correcting mutations responsible for pathological phenotypes. In this video, Dr. Evangelos Kiskinis, Assistant Professor of Neurology and Neuroscience at Northwestern University, shares his work using patient-specific iPSC-derived systems to understand how rare genetic mutations impact the function of human neuronal subtypes and contribute toward neurological diseases such as amyotrophic lateral sclerosis (ALS) or pediatric forms of epilepsies.