Epigenomics plays a crucial role in oncology by unraveling the intricate molecular modifications that influence gene expression patterns and provide valuable insights into cancer development, progression, and potential therapeutic targets. In this video, Dr. Jorg Tost, Head, Laboratory for Epigenetics & Environment at CEA – IBFJ, discusses his work identifying epigenetic changes that can be used for the next generation of personalized medicine including in immune-oncology applications. Prof. Martin Hirst, Professor and Director, Michael Smith Laboratories, The University of British Columbia, also describes his research which is focused on developing our understanding of epigenomics further through his work at the International Human Epigenome Consortium (IHEC).