The term 'microbiome' defines the community of symbiotic, commensal, and parasitic microorganisms and viruses that co-inhabit an environment. In this presentation, Dr. Raul Cano, Chief Scientific Officer at The BioCollective, discusses the clinical applications of the microbiome, current research challenges in the clinic, and how to interpret microbiome data. This talk was presented at the SelectScience® Virtual Microbiology and Infectious Disease Summit 2022.