Dashinimaev Erdem, Ph.D., of The Pirogov Russian National Research Medical University, outlines his research into gene dosage imbalance in patients with Down's Syndrome (Trisomy 21). His team has created a cell-based model deriving from iPSCs with Trisomy 21, with the aim of elucidating how the presence of an extra copy of chromosome 21 leads to pathological events.