Heart failure is a common diagnosis caused by different forms of heart disease. In this video, Dr. James Januzzi, Hutter Family Professor of Medicine at Harvard Medical School and Cardiologist at Massachusetts General Hospital, discusses the role of natriuretic peptides BNP and NT-proBNP as biomarkers for the evaluation of acute and chronic heart failure, global clinical guidelines around their use, and his thoughts on the future of heart failure diagnosis, management and prognosis, including the impact of point of care.