In this video, filmed on December 9, 2019, Prof. Junichi Ishii from Fujita Health University Hospital demonstrates how to use high-sensitivity troponin I assays and a 1-hour algorithm to rule in and rule out myocardial infarction in patients presenting to the emergency department. He discusses that these new assays may also be used during health checks, to identify patients at high risk of having an acute cardiac event in the future. Prof. Ishii also explains how the Siemens High-Sensitivity Troponin I assay meets the European Society of Cardiology (ESC) guidelines for this type of assay.