Dr. Theodossis Theodossiou
Oslo University Hospital
Dr. Theodossis Theodossiou is a senior researcher, and project group leader in the area "Protonics" at the Institue for Cancer Research, Oslo University Hospital. His reasearch group is carrying out research on the use of ionising and non-ionising radiation as cancer therapeutics The main aim of the PROTONICs team is the combinatory use of ionising radiation-based therapies like Proton Therapy and/or Neutron Capture Therapy, together with light based therapies, like Photodynamic Therapy (PDT) or Photochemical Internalisation to achieve a breakthrough anticancer strategy. This multifaceted effort also employs the use of cancer-specific nanoparticles, the use of innovative intracellular light sources for PDT, the interplay between various reactive oxygen species and the use of the cancer cells’ own devices to defeat them. The team further specialises in mitochondrial bioenergetics, the effect of various assaults (chemical, photochemical or radiative) on the mitochondrial respiration and the consequent interplay between respiratory and glycolytic cell metabolism. Our niche is the design and exploration of novel high risk – high gain experimental therapeutics, including not previously envisaged or anticipated strategies. Our activities are currently supported by local (Helse Sor Ost) as well as European funding (Future and Emerging Technologies and Euronanomed).
