In this presentation, Dr. Michael Laposata reviews the different testing platforms currently used for COVID-19 testing and highlights the challenges faced by healthcare practitioners in reaching accurate and reliable diagnostic conclusions. Laposata provides insight into how to overcome the occurrence of false negatives and false positives, highlights the need for high performing ELISA and chemiluminescence assays without cross-reactivity, and describes how the provision of test result interpretations could greatly reduce diagnostic errors, with significant clinical consequences.